Challenges associated with nerve conduction block using kilohertz electrical stimulation.

Differential fiber-specific block of nerve conduction in mammalian peripheral nerves using kilohertz electrical stimulation.

Kilohertz electrical stimulation (KES) has been shown to induce repeatable and reversible nerve conduction block in animal models. In this study, we characterized the ability of KES stimuli to selectively block specific components of stimulated nerve activity using in vivo preparations of the rat sciatic and vagus nerves. KES stimuli in the frequency range of 5-70 kHz and amplitudes of 0.1-3.0 ...

Innovative Methodology Differential fiber-specific block of nerve conduction in mammalian peripheral nerves using kilohertz electrical stimulation

Patel YA, Butera RJ. Differential fiber-specific block of nerve conduction in mammalian peripheral nerves using kilohertz electrical stimulation. J Neurophysiol 113: 3923–3929, 2015. First published April 15, 2015; doi:10.1152/jn.00529.2014.—Kilohertz electrical stimulation (KES) has been shown to induce repeatable and reversible nerve conduction block in animal models. In this study, we charac...

Title : Differential fiber - specific block of nerve conduction in mammalian peripheral nerves using kilohertz electrical stimulation

Conduction block in myelinated axons induced by high-frequency (kHz) non-symmetric biphasic stimulation

This study used the Frankenhaeuser-Huxley axonal model to analyze the effects of non-symmetric waveforms on conduction block of myelinated axons induced by high-frequency (10-300 kHz) biphasic electrical stimulation. The results predict a monotonic relationship between block threshold and stimulation frequency for symmetric waveform and a non-monotonic relationship for non-symmetric waveforms. ...

Asymmetric Rectangular Waveform in Stimulation with High Frequency Alternating Current Reduces the Threshold for Neural Conduction Block

Introduction Abnormal neural impulses in the nervous system may lead to various diseases and disabilities. High frequency alternating currents (HFAC) has been used to block the propagation of such impulses and improve the symptoms or disabilities. The technique is safe, reversible, and relatively selective, and its reliability, the optimum stimulation parameters, and elimination of the onset re...